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Epicutis® Exclusive Ingredients

Below are proprietary ingredients developed by Signum Biosciences to be used exclusively in the Epicutis® product line.

TSC

Tetramethyl Hexadecenyl Succinoyl Cysteine

TSC (tetramethylhexadecenyl succinoyl cysteine) is a patented, next-generation molecule that acts as a super-lipid—restoring the skin’s natural barrier while targeting key inflammatory pathways, supporting healthier, more resilient skin—without irritation.

TSC

HYVIA®

Salvia Hispanica Seed Oil Extract

HYVIA® (salvia hispanica) a novel moisturizing agent derived from organic non-GMO chia seed oil, delivers stable potent omega-3 and omega-6 fatty acids—to help boost hydration, calm inflammation, and fight other visible signs of poor skin health.

HYVIA®

DSD

Disodium S-Phytyl Diglycoloylcysteine

DSD (disodium S-phytyl diglycoloylcysteine) is a lipid-like mimetic similar to TSC equipped with powerful, anti-oxidant properties that protect against environmental stressors by blocking UV and pollution induced skin damage.

DSD

AGSE

Activated Grape Seed Extract

AGSE (activated grape seed extract) is a novel grape seed extract clinically proven to combat fine lines and wrinkles that possesses strong anti-oxidant and anti-Inflammatory properties to help calm skin and fight the signs of aging.

AGSE

ABSO

Arctigenin Enriched Burdock Seed Oil

ABSO (arctigenin enriched burdock seed oil) is a novel skin-brightening extract derived from burdock seed oil. It’s enriched with arctigenin (ATG) - the key skin brightening component. Containing about 5 times more ATG than regular burdock seed oil (BSO).

ABSO

QFC

Acetylglutaminoyl Farnesylcysteine

QFC (acetylglutaminoyl farnesylceysteine) is a powerful anti-oxidant able to increase hydration and the production of HO-1 which directly contributes to the break down of dark under-eye circles.

QFC

Ingredient Library

Below are all of the ingredients that exist within our product formulations.

Water

Water is the universal solvent and primary vehicle in skincare, delivering hydration and supporting the skin’s moisture balance. It acts as the base for most formulations, enhances ingredient absorption, and maintains product texture and stability, making it essential for healthy, supple skin.

Water

Zinc Gluconate

Zinc Gluconate is a water-soluble zinc salt with antibacterial, anti-inflammatory, and sebum-regulating properties that control oil, calm irritation, and prevent breakouts. As an antioxidant, it protects against free radicals and supports skin healing, making it ideal for oily, sensitive, and acne-prone complexions.

Zinc Gluconate

Triethyl Citrate

Triethyl Citrate is a naturally derived ester that acts as an emollient, antimicrobial, and fragrance fixative. It provides lightweight hydration, lowers skin pH to neutralize odor-causing bacteria, and enhances texture and stability, making it ideal for deodorants, perfumes, and skincare formulas focused on oil control and antimicrobial defense.

Triethyl Citrate

Tocopherol

Tocopherol (vitamin E) is a fat-soluble antioxidant that protects skin from oxidative stress and environmental damage. It neutralizes free radicals, strengthens the barrier, locks in moisture, and soothes irritation—reducing visible aging and supporting hydration, repair, and overall skin health in creams, serums, sunscreens, and makeup.

Tocopherol

Synthetic Fluorphlogopite

Synthetic Fluorphlogopite is a synthetic mica used in cosmetics for bulking, viscosity control, and pearlescent shimmer. It enhances texture, slip, and soft-focus effects, and is chemically inert, non-irritating, and safe at typical use levels.

Synthetic Fluorphlogopite

Stearyl Alcohol

Stearyl Alcohol is a plant-derived fatty alcohol that softens and smooths skin by creating a moisture-locking barrier. It also stabilizes and thickens emulsions, imparting a creamy texture and preventing separation in lotions, creams, and conditioners.

Stearyl Alcohol

Steareth-20

Steareth-20 is an ethoxylated stearyl alcohol emulsifier that stabilizes oil-in-water mixtures, improves texture, and dissolves trace oils in water-based formulas. Its nonionic nature and HLB of ~15.3 make it effective at 1–5% in creams, lotions, cleansers, and sunscreens, delivering smooth, non-greasy, and stable products with minimal irritation.

Steareth-20

Spilanthes Acmella Flower Extract

Spilanthes Acmella Flower Extract is a spilanthol-rich botanical that relaxes facial muscles to reduce fine lines, while offering antioxidant, anti-inflammatory, and collagen-boosting benefits for firmer, smoother skin.

Spilanthes Acmella Flower Extract

Sodium Phytate

Sodium Phytate is the sodium salt of phytic acid that chelates metal ions to stabilize and preserve skincare products while enhancing preservative performance. Additionally, it gently exfoliates and brightens skin, boosts hydration and elasticity, balances oil production, and refines pores, making it a versatile addition to water-based serums, creams, and cleansers.

Sodium Phytate

Sodium Lauroyl Glutamate

Sodium Lauroyl Glutamate gently cleanses and foams while conditioning skin and hair, stabilizing emulsions, and reducing static. Its amino-acid base and wide pH tolerance ensure mildness and biodegradability, making it a preferred surfactant in natural, sensitive-skin, and baby care formulations.

Sodium Lauroyl Glutamate

Sodium Hyaluronate

Sodium Hyaluronate is the sodium salt of hyaluronic acid that penetrates deeply to bind moisture, plump skin, and smooth fine lines. It forms a protective, lightweight film to reduce water loss and calm inflammation, making it an essential humectant for dry, sensitive, and aging skin in serums, creams, and masks.

Sodium Hyaluronate

Sodium Citrate

Sodium citrate is a pH-buffering and chelating agent that stabilizes cosmetic formulations by maintaining acidic pH and sequestering metal ions, while its mild antioxidant and preservative actions protect against microbial spoilage.

Sodium Citrate

Silica

Silica is a fine silicon dioxide powder that absorbs oil and moisture to deliver a matte, soft-focus finish while refining texture and minimizing pores. It also supports collagen production and barrier hydration, making it ideal for formulations targeting shine control, pore refinement, and anti-aging benefits.

Silica

Protease

Protease is an enzyme exfoliant that breaks down intercellular protein bonds to release dead skin cells, refining texture and stimulating renewal. It enhances product efficacy by improving penetration and mimicking natural desquamation, making it suitable for cleansers, masks, and peels aimed at smoothing, brightening, and anti-aging treatments.

Protease

Propanediol

Propanediol is a corn-derived humectant and solvent that boosts hydration, smooths texture, and supports the skin barrier with a lightweight, non-sticky feel. It enhances ingredient penetration, improves preservative efficacy, and stabilizes formulations, serving as a sustainable alternative to propylene glycol for all skin types.

Propanediol

PPG-13-Decyltetradeceth-24

PPG-13-Decyltetradeceth-24 is a PEG/PPG emulsifier and surfactant that stabilizes and solubilizes oil and water phases, enhances texture, and provides gentle cleansing with low irritation potential.

PPG-13-Decyltetradeceth-24

Polyglyceryl-2 Sesquioleate

Polyglyceryl-2 Sesquioleate is a plant-derived water-in-oil emulsifier that creates smooth, non-greasy textures and improves spreadability and absorption. With gentle surfactant and antimicrobial properties, it serves as a versatile primary or co-emulsifier, ideal for sensitive, acne-prone, and high-performance skincare formulations.

Polyglyceryl-2 Sesquioleate

Polyglyceryl-2 Caprate

Polyglyceryl-2 Caprate is a plant-derived emulsifier and surfactant that stabilizes oil-water blends for smooth, non-greasy textures. It enhances hydration by reducing water loss and offers mild antimicrobial and conditioning benefits, making it ideal for cleansers, lotions, and makeup in sensitive or acne-prone skincare formulations.

Polyglyceryl-2 Caprate

Phytosterols

Phytosterols are plant-derived sterols that mimic skin cholesterol to reinforce the lipid barrier, enhance hydration, and reduce transepidermal water loss. They also deliver anti-inflammatory and antioxidant benefits, making them ideal for soothing, repairing, and protecting dry or sensitive complexions.

Phytosterols

Pentylene Glycol

Pentylene Glycol is a plant-derived diol that functions as a humectant and solvent to attract moisture, stabilize emulsions and boost preservative performance in skincare formulations. Its antimicrobial properties and low molecular weight support hydration, texture enhancement and ingredient delivery without irritating sensitive skin.

Pentylene Glycol

Rice Bran Oil

Oryza Sativa Bran Oil is a lightweight emollient rich in oleic and linoleic acids that strengthens the skin barrier and locks in moisture. Its high antioxidant content—including γ-oryzanol, vitamin E isomers, and ferulic acid—provides photoprotection and anti-aging support while soothing inflammation.

Rice Bran Oil

Evening Primrose Seed Extract

Oenothera Biennis (Evening Primrose) Seed Extract is a lightweight emollient rich in linoleic and gamma-linolenic acids that strengthens the skin barrier and locks in moisture. Its anti-inflammatory and antioxidant properties soothe irritation, support repair, and provide lasting hydration, making it ideal for dry, sensitive, or inflamed skin.

Evening Primrose Seed Extract

Lychee Seed Extract

Nephelium Longana Seed Extract is a polyphenol-rich botanical ingredient that delivers antioxidant, anti-inflammatory, and skin-conditioning benefits by neutralizing free radicals and strengthening the skin barrier. It also enhances microcirculation and inhibits cellulite-related pathways, improving skin smoothness and hydration without clogging pores.

Lychee Seed Extract

Maltodextrin

Maltodextrin is a starch-derived oligosaccharide that acts as a humectant and moisture-binder, helping to maintain skin hydration and reduce water loss. It also stabilizes emulsions and improves texture as a bulking agent, while its film-forming and absorbent properties mattify skin and enhance product stability.

Maltodextrin

Macadamia Seed Oil

Macadamia Integrifolia Seed Oil is a non-comedogenic, sebum-similar emollient rich in oleic and palmitoleic acids that deeply hydrates, supports barrier repair, and soothes inflammation while delivering antioxidant protection. It absorbs quickly to improve skin elasticity and moisture retention, making it perfect for formulations targeting dry, sensitive, or mature skin.

Macadamia Seed Oil

Lipase

Lipase hydrolyzes skin surface fats into fatty acids and glycerol, delivering deep cleansing, gentle exfoliation, and sebum regulation. It unclogs pores and refines texture by removing excess oils while moisturizing with the released glycerol. In skincare, lipase serves as a dual-action cleansing and conditioning agent, ideal for oily or acne-prone skin.

Lipase

Meadowfoam Seed Oil

Meadowfoam Seed Oil is a stable, non-greasy emollient composed of 95% long-chain fatty acids that locks in moisture, reduces water loss, and promotes smooth, conditioned skin while enhancing formulation stability.

Meadowfoam Seed Oil

Isocetyl Alcohol

Isocetyl Alcohol is a C16 fatty alcohol that functions as an emollient, skin conditioner, and viscosity controller, forming a lightweight barrier to lock in moisture and prevent water loss. It also acts as a self-emulsifier to stabilize and improve the texture of creams and lotions, making it invaluable for hydrating formulations suited to dry, sensitive, or mature skin.

Isocetyl Alcohol

Hydroxyethyl Urea

Hydroxyethyl Urea is a low-molecular-weight humectant that deeply hydrates and strengthens the skin barrier by reducing water loss and improving elasticity. More effective than glycerin, it offers a smooth, non-sticky feel and enhances formula stability, providing intense, irritation-free hydration for all skin types, including dry and sensitive skin.

Hydroxyethyl Urea

Hydrolyzed Sodium Hyaluronate

Hydrolyzed Sodium Hyaluronate is a low-molecular-weight hyaluronic acid that deeply hydrates, strengthens the skin barrier, and boosts natural HA production. It reduces transepidermal water loss, enhances elasticity, and smooths fine lines, making it ideal for hydrating and anti-aging formulas targeting dry, sensitive, or compromised skin.

Hydrolyzed Sodium Hyaluronate

Sunflower Seed Oil

Helianthus Annuus (Sunflower) Seed Oil is a lightweight, non-comedogenic moisturizer rich in linoleic acid that strengthens the skin barrier, prevents water loss, and supports ceramide synthesis. Offering anti-inflammatory and antioxidant benefits, it soothes, protects, and hydrates all skin types, including sensitive, dry, and acne-prone complexions.

Sunflower Seed Oil

Glyceryl Stearate SE

Glyceryl Stearate SE is a plant-derived self-emulsifying agent that binds oil and water to create smooth, stable formulations. Acting as an emollient and barrier protector, it locks in moisture, reduces transepidermal water loss, and delivers a soft, non-greasy feel—ideal for hydrating, lightweight skincare suitable for all skin types.

Glyceryl Stearate SE

Glycerin

Glycerin is a powerful natural humectant that draws moisture to the skin, creating a lasting hydration reservoir. It penetrates through aquaporin-3 channels to strengthen the barrier, support cell membrane fluidity, and enhance other ingredients—making it ideal for dry, sensitive, or compromised skin and suitable for all skin types.

Glycerin

Glucosylrutin

Glucosylrutin is a highly water-soluble derivative of rutin, a flavonoid from buckwheat and citrus. It delivers potent antioxidant and anti-inflammatory benefits, neutralizing UV-induced free radicals to protect against oxidative stress and photoaging. In skincare, it reduces inflammation, prevents damage, and reinforces the skin’s natural defense system.

Glucosylrutin

Glucosyl Hesperidin

Glucosyl Hesperidin is a water-soluble citrus flavonoid derivative with enhanced bioavailability. As a potent antioxidant and anti-inflammatory, it boosts microcirculation to reduce dark circles, puffiness, and dullness. In skincare, it acts as a humectant and conditioning agent, maintaining hydration while strengthening capillaries and improving overall skin tone.

Glucosyl Hesperidin

Ferulic Acid

Ferulic Acid is a plant-derived antioxidant found in rice bran, oats, and fruits that protects against free radicals and UV damage. It reduces inflammation, brightens by inhibiting melanogenesis, and preserves collagen and elastin. In skincare, it enhances vitamin E’s efficacy, offering superior protection from oxidative stress and environmental damage.

Ferulic Acid

Dihydroxylignoceroyl Phytosphingosine

Dihydroxylignoceroyl Phytosphingosine is a plant-derived ceramide that restores the skin’s lipid barrier, improves hydration and elasticity, and protects against environmental stressors. With a skin-identical structure, it effectively repairs dry, sensitive, or compromised skin and is commonly used in moisturizers and barrier-repair formulations for all skin types.

Dihydroxylignoceroyl Phytosphingosine

Citric Acid

Citric Acid is a naturally occurring AHA that balances pH, exfoliates, and enhances preservation. It gently removes dead skin cells for smoother, brighter skin, helps unclog pores and fade dark spots, and stabilizes formulations by binding metal ions that could otherwise cause oxidation or product degradation.

Citric Acid

Hinoki Wood Oil

Chamaecyparis Obtusa Wood Oil is an antimicrobial, anti-inflammatory essential oil that soothes irritation, supports barrier repair, and protects the skin. Rich in antioxidants and wound-healing properties, it’s ideal for sensitive or blemish-prone skin, while its calming aroma promotes relaxation and stress relief in skincare and wellness formulations.

Hinoki Wood Oil

Cetyl Alcohol

Cetyl Alcohol is a plant-derived or synthetic fatty alcohol that acts as an emollient, emulsifier, and thickener in skincare and haircare products, creating a creamy texture while locking in moisture and improving product stability. It forms a protective barrier to reduce water loss, is non-comedogenic, and is suitable for sensitive, dry, or mature skin and hair.

Cetyl Alcohol

Ceramide NP

Ceramide NP is a skin-identical lipid that restores and strengthens the skin barrier, locks in moisture, and protects against environmental stressors. It soothes irritation, enhances hydration, and is especially beneficial for dry, sensitive, or compromised skin, making it a key ingredient in barrier-repair and moisturizing formulations.

Ceramide NP

Ceramide AP

Ceramide AP is a synthetic ceramide that strengthens the skin barrier, improves hydration, and supports gentle cell renewal. Its deeply penetrating structure provides long-lasting protection, helping repair dry, sensitive, or aging skin while minimizing fine lines, irritation, and moisture loss for a smoother, healthier complexion.

Ceramide AP

Carbomer

Carbomer is a synthetic polymer that thickens, stabilizes, and creates smooth gel textures in skincare formulations. It absorbs water to enhance viscosity, consistency, and spreadability while preventing separation. Non-comedogenic and non-irritating, it’s widely used in creams, lotions, gels, and serums suitable for all skin types.

Carbomer

Capric Triglyceride

Caprylic/Capric Triglyceride is a plant-derived emollient that creates a lightweight, non-greasy barrier to lock in moisture and smooth skin texture. It also stabilizes formulations and enhances ingredient absorption, improving hydration and product performance in creams, lotions, and makeup for all skin types without clogging pores.

Capric Triglyceride

Caffeine

Caffeine is a powerful antioxidant and anti-inflammatory that protects against free radicals, reduces puffiness and redness, and firms skin for a brighter, more youthful look. Its vasoconstrictive action minimizes dark circles and under-eye bags, while its soothing benefits suit all skin types in serums, creams, and eye treatments.

Caffeine

Shea Butter

Butyrospermum Parkii (Shea) Butter is a nutrient-rich emollient high in oleic and stearic acids that deeply hydrates and locks in moisture. Rich in vitamins A and E, it soothes irritation, supports collagen, and repairs dry or damaged skin, offering long-lasting hydration and protection for all skin types.

Shea Butter

Ammonium Acryloyldimethyltaurate

Ammonium Acryloyldimethyltaurate/VP Copolymer is a synthetic polymer that thickens, stabilizes, and forms a smooth film in skincare products. It creates a lightweight, velvety texture, enhances formulation stability, and locks in moisture. Compatible with diverse ingredients, it’s ideal for all skin types and modern gel or cream formulations.

Ammonium Acryloyldimethyltaurate