

From bench to shelf.
Epicutis® represents the forefront of skincare innovation, bringing together a team of respected scientists and health advocates united by a common goal: to bring real, measurable value to skincare.
In a field frequently dominated by empty promises and passing fads, we've dedicated ourselves to creating a new benchmark—one based on thorough research, observable results, and steadfast integrity.
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Clean + Simple
We focus on what really matters.

Skin Health Focus
Epicutis® was created to provide tools for everyone to care for the health of their skin, their body's largest organ. With only three steps, twice daily, you can effectively and efficiently care for and improve the health of your skin.

Clinician Centric
At the heart of our business is the relationship between client and clinician. As we begin our aesthetic journey to improve our skin health and appearance, we all require the help of the industry's true experts, clinicians. Our mission is to protect their business, and provide tools and resources for clinicians to do what they do best - Care for skin.

Constant Innovation
Our biotech background means we have an R&D team focused on developing new ingredients and formulations to continue to improve how we care for our skin. The ingredients we have on market today required years of development before arriving to you in a final formulation. Ingredients we are developing now won't be formulated for years as we ensure safety and efficacy across the entire list of ingredients.
Our History

1991
Discovery of Novel Signal Transduction Modulators (STMs)
Dr. Jeffry Stock discovered the power of a specific class of small molecules in his lab at Princeton where he modified S-farnesylcysteine into an active signal transduction molecule. The modifications made to this compound serves as the initial building blocks of our STM technology platform.

2003
Signum Founded
Dr. Stock and his son Maxwell Stock founded Signum Biosciences Inc.®, a biotechnology company spun out of Princeton University, whose focus is to develop novel ingredients for both the cosmetic and pharmaceutical space.

2008
TSC is Discovered
By continuing to modify small molecules in order to yield skin benefitting effects, TSC was created. Its ability to repair skin, lower inflammation and many other skin health promoting properties makes it a unique ingredient without comparison

2016
Masanori Tamura Joins Our Team
Signum’s corporate partner Rohto Pharmaceutical’s top formulator Masanori Tamura is the developer of Japan’s #1 moisturizer line Hada Labo. Tamura’s high-quality formulation efforts at Rohto attracted to the Signum Team’s attention while he was working in the US. After collaborating, Tamura joined the Signum team as our head formulator and director of Product Development.

2019
Hyvia® is Discovered
Our development of botanical extracts began as an interest in the foods we know to be therapeutic. By studying foods that humans already crave and consume we can make assumptions on why these foods are sought after. Chia seeds are exceptionally powerful and when put through our patented extraction process, yields a novel, proprietary topical oil that improves skin hydration and barrier function unlike any other on the market.

2020
Epicutis® is Created
After 20 years of dermatology focused R&D, Epicutis® is launched using unique, patented ingredients in simple formulations. We have created two products to help maintain skin health rather than trying to address the surface level symptoms of our skin.