Cause > Effect
At Epicutis® we develop skincare ingredients to care for our skin's overall health, not its appearance. We have grown tired of the tricks of the trade, with promises of appearance becoming more important than how a product impacts our health.
To us it's simple. Your skin is a reflection of your health -- and we need to care for it as such. The tendency to focus on appearance is natural, but it is important to remember, Cause > Effect.
Our History
1991
Discovery of Novel Signal Transduction Modulators (STMs)
Dr. Jeffry Stock discovered the power of a specific class of small molecules in his lab at Princeton where he modified S-farnesylcysteine into an active signal transduction molecule. The modifications made to this compound serves as the initial building blocks of our STM technology platform.
2003
Signum Founded
Dr. Stock and his son Maxwell Stock founded Signum Biosciences Inc., a biotechnology company spun out of Princeton University, whose focus is to develop novel ingredients for both the cosmetic and pharmaceutical space.
2008
TSC is Discovered
By continuing to modify small molecules in order to yield skin benefitting effects, TSC was created. Its ability to repair skin, lower inflammation and many other skin health promoting properties makes it a unique ingredient without comparison
2016
Masanori Tamura Joins Our Team
Signum’s corporate partner Rohto Pharmaceutical’s top formulator Masanori Tamura is the developer of Japan’s #1 moisturizer line Hada Labo. Tamura’s high-quality formulation efforts at Rohto attracted to the Signum Team’s attention while he was working in the US. After collaborating, Tamura joined the Signum team as our head formulator and director of Product Development.
2019
Hyvia® is Discovered
Our development of botanical extracts began as an interest in the foods we know to be therapeutic. By studying foods that humans already crave and consume we can make assumptions on why these foods are sought after. Chia seeds are exceptionally powerful and when put through our patented extraction process, yields a novel, proprietary topical oil that improves skin hydration and barrier function unlike any other on the market.
2020
Epicutis® is Created
After 20 years of dermatology focused R&D, Epicutis® is launched using unique, patented ingredients in simple formulations. We have created two products to help maintain skin health rather than trying to address the surface level symptoms of our skin.
Our Ingredients
Over the last 20 years, Signum Biosciences Inc., has developed a library of novel ingredients focusing on two very specific targets.
Selecting Targets
Over the last 20 years, Signum Biosciences Inc., has developed a library of novel ingredients focusing on two very specific targets.
IPC's - Signal Transduction Modifiers
Our skin's cells are constantly sending signals to one another in the form of proteins, enzymes, and other molecules. By modulating how these signals are sent we can adjust our skin's response to certain stimuli.
PP2A - Fighting Inflammation
Within each of our skin's cells is a protein trimer called PP2A. By activating PP2A we are able to decrease the levels of inflammation in skin to improve natural repair.
Research + Development
Applying the tools of pharmaceutical development to cosmetic development
At Epicutis® we have the ability to conduct science on the level of major pharmaceutical companies because our origins are in biotechnology. For most cosmetic products, R&D is an afterthought or a tool to drive marketing rather than a way to create something with true value.
Team of Scientists
Signum's research and development team is comprised of seasoned scientists and phD's specializing in Chemistry, Biology, Microbiology, and more. We've taken the last 20 years of experience to create a team of scientific operators.
Next Level Facilities
Signum is one of the most capable biotech companies globally - able to navigate the rigors of drug development while also being able to take a product to market. Our equipment and facilities allow us to usher in a new paradigm in skincare.
Frequently Published
One of our superpowers other than our amazing team of scientists are their ability to publish our research in peer-reviewed publications. These publications, unlike white papers, face the scrutiny of the scientific community where our findings are tested and compared with teams conducting these experiments completely separate of Signum. Papers that do not qualify do not get published.